Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3A
Ligand
BDBM80546
Substrate
n/a
Meas. Tech.
Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay
Temperature
298.15±n/a K
IC50
1890±n/a nM
Comments
extracted
Citation
PubChem, PC Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3A
Synonyms:
ABC3A_HUMAN | APOBEC3A | probable DNA dC->dU-editing enzyme APOBEC-3A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23013.77
Organism:
Homo sapiens (Human)
Description:
gi_21955158
Residue:
199
Sequence:
MEASPASGPRHLMDPHIFTSNFNNGIGRHKTYLCYEVERLDNGTSVKMDQHRGFLHNQAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFKHCWDTFVDHQGCPFQPWDGLDEHSQALSGRLRAILQNQGN
Inhibitor
Name:
BDBM80546
Synonyms:
1-{2-[(5-Dimethylsulfamoyl-furan-2-carbonyl)-amino]-ethyl}-1-methyl-azepanium | 5-(dimethylsulfamoyl)-N-[2-(1-methyl-1-azepan-1-iumyl)ethyl]-2-furancarboxamide;iodide | 5-(dimethylsulfamoyl)-N-[2-(1-methylazepan-1-ium-1-yl)ethyl]-2-furamide;iodide | 5-(dimethylsulfamoyl)-N-[2-(1-methylazepan-1-ium-1-yl)ethyl]furan-2-carboxamide;iodide | MLS001212477 | SMR000518608 | cid_24747087
Type:
Small organic molecule
Emp. Form.:
C16H28N3O4S
Mol. Mass.:
358.476
SMILES:
CN(C)S(=O)(=O)c1ccc(o1)C(=O)NCC[N+]1(C)CCCCCC1
Structure:
