Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3A
Ligand
BDBM80556
Substrate
n/a
Meas. Tech.
Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay
Temperature
298.15±n/a K
IC50
1750±n/a nM
Comments
extracted
Citation
PubChem, PC Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3A
Synonyms:
ABC3A_HUMAN | APOBEC3A | probable DNA dC->dU-editing enzyme APOBEC-3A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23013.77
Organism:
Homo sapiens (Human)
Description:
gi_21955158
Residue:
199
Sequence:
MEASPASGPRHLMDPHIFTSNFNNGIGRHKTYLCYEVERLDNGTSVKMDQHRGFLHNQAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFKHCWDTFVDHQGCPFQPWDGLDEHSQALSGRLRAILQNQGN
Inhibitor
Name:
BDBM80556
Synonyms:
4-[[4-[(Z)-2-cyano-3-oxidanylidene-3-phenylazanyl-prop-1-enyl]phenoxy]methyl]benzoic acid | 4-[[4-[(Z)-3-anilino-2-cyano-3-keto-prop-1-enyl]phenoxy]methyl]benzoic acid | 4-[[4-[(Z)-3-anilino-2-cyano-3-oxoprop-1-enyl]phenoxy]methyl]benzoic acid | MLS001173501 | SMR000538783 | cid_1924058
Type:
Small organic molecule
Emp. Form.:
C24H18N2O4
Mol. Mass.:
398.4107
SMILES:
OC(=O)c1ccc(COc2ccc(\C=C(\C#N)C(=O)Nc3ccccc3)cc2)cc1
Structure:
