Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3A
Ligand
BDBM61355
Substrate
n/a
Meas. Tech.
Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay
Temperature
298.15±n/a K
IC50
2240±n/a nM
Comments
extracted
Citation
PubChem, PC Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3A
Synonyms:
ABC3A_HUMAN | APOBEC3A | probable DNA dC->dU-editing enzyme APOBEC-3A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23013.77
Organism:
Homo sapiens (Human)
Description:
gi_21955158
Residue:
199
Sequence:
MEASPASGPRHLMDPHIFTSNFNNGIGRHKTYLCYEVERLDNGTSVKMDQHRGFLHNQAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFKHCWDTFVDHQGCPFQPWDGLDEHSQALSGRLRAILQNQGN
Inhibitor
Name:
BDBM61355
Synonyms:
5-ethyl-6-keto-benzo[b][1,4]benzothiazepine-3-carboxylic acid ethyl ester | 5-ethyl-6-oxo-3-benzo[b][1,4]benzothiazepinecarboxylic acid ethyl ester | MLS001200975 | SMR000564432 | cid_4083983 | ethyl 10-ethyl-11-oxo-10,11-dihydrodibenzo[b,f][1,4]thiazepine-8-carboxylate | ethyl 5-ethyl-6-oxidanylidene-benzo[b][1,4]benzothiazepine-3-carboxylate | ethyl 5-ethyl-6-oxobenzo[b][1,4]benzothiazepine-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C18H17NO3S
Mol. Mass.:
327.397
SMILES:
CCOC(=O)c1ccc2Sc3ccccc3C(=O)N(CC)c2c1
Structure:
