Reaction Details Report a problem with these data
Target
Tropomyosin alpha-1 chain
Ligand
BDBM50473
Substrate
n/a
Meas. Tech.
Fluorescence-based biochemical high throughput dose response assay for inhibitors of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF)
IC50
20888±n/a nM
Citation
 PubChem, PC Fluorescence-based biochemical high throughput dose response assay for inhibitors of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) PubChem Bioassay (2011)[AID] 
Target
Name:
Tropomyosin alpha-1 chain
Synonyms:
TPM1 | TPM1_PIG | cardiac alpha tropomyosin
Type:
Enzyme Catalytic Domain
Mol. Mass.:
32681.01
Organism:
Sus scrofa
Description:
P42639
Residue:
284
Sequence:
MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKRLEDELVSLQKKLKATEDELDKYSEAPKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDKYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSI
  
Inhibitor
Name:
BDBM50473
Synonyms:
2,3-bis(2-furanyl)-6-quinoxalinecarboxylic acid | 2,3-bis(2-furyl)quinoxaline-6-carboxylic acid | 2,3-bis(furan-2-yl)quinoxaline-6-carboxylic acid | MLS000713832 | SMR000273313 | cid_774142
Type:
Small organic molecule
Emp. Form.:
C17H10N2O4
Mol. Mass.:
306.2723
SMILES:
OC(=O)c1ccc2nc(-c3ccco3)c(nc2c1)-c1ccco1
Structure:
Search PDB for entries with ligand similarity: