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Target
Nicotinate-nucleotide adenylyltransferase
Ligand
BDBM81358
Substrate
n/a
Meas. Tech.
Enzymatic Inhibition Assay
IC50
5.1e+4±n/a nM
Citation
 Sorci, L; Pan, Y; Eyobo, Y; Rodionova, I; Huang, N; Kurnasov, O; Zhong, S; MacKerell, AD; Zhang, H; Osterman, AL Targeting NAD biosynthesis in bacterial pathogens: Structure-based development of inhibitors of nicotinate mononucleotide adenylyltransferase NadD. Chem Biol 16:849-61 (2009) [PubMed]  Article 
Target
Name:
Nicotinate-nucleotide adenylyltransferase
Synonyms:
Deamido-NAD(+) pyrophosphorylase | NADD_ECOLI | Nicotinate mononucleotide adenylyltransferase (NadD) | Nicotinate-nucleotide adenylyltransferase (NadD) | nadD | ybeN
Type:
Enzyme
Mol. Mass.:
24523.61
Organism:
Escherichia coli
Description:
P0A752
Residue:
213
Sequence:
MKSLQALFGGTFDPVHYGHLKPVETLANLIGLTRVTIIPNNVPPHRPQPEANSVQRKHMLELAIADKPLFTLDERELKRNAPSYTAQTLKEWRQEQGPDVPLAFIIGQDSLLTFPTWYEYETILDNAHLIVCRRPGYPLEMAQPQYQQWLEDHLTHNPEDLHLQPAGKIYLAETPWFNISATIIRERLQNGESCEDLLPEPVLTYINQQGLYR
  
Inhibitor
Name:
BDBM81358
Synonyms:
NadD inhibitor 3_15 | US8785499, 3_15
Type:
Small organic molecule
Emp. Form.:
C18H11ClFN3OS2
Mol. Mass.:
403.881
SMILES:
Nc1c(sc2nc(ccc12)-c1cccs1)C(=O)Nc1ccc(Cl)cc1F
Structure:
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