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Target
Probable nicotinate-nucleotide adenylyltransferase
Ligand
BDBM81359
Substrate
n/a
Meas. Tech.
Enzymatic Inhibition Assay
IC50
3.3e+4±n/a nM
Citation
 Sorci, L; Pan, Y; Eyobo, Y; Rodionova, I; Huang, N; Kurnasov, O; Zhong, S; MacKerell, AD; Zhang, H; Osterman, AL Targeting NAD biosynthesis in bacterial pathogens: Structure-based development of inhibitors of nicotinate mononucleotide adenylyltransferase NadD. Chem Biol 16:849-61 (2009) [PubMed]  Article 
Target
Name:
Probable nicotinate-nucleotide adenylyltransferase
Synonyms:
BAMEG_4595 | Deamido-NAD(+) diphosphorylase | Deamido-NAD(+) pyrophosphorylase | NADD_BACAC | Nicotinate mononucleotide adenylyltransferase | Nicotinate-nucleotide adenylyltransferase | Nicotinate-nucleotide adenylyltransferase (NadD) | Nicotinic acid mononucleotide adenylyltransferase (NaMNAT) | nadD
Type:
Enzyme
Mol. Mass.:
21955.08
Organism:
Bacillus anthracis
Description:
C3L5T6
Residue:
189
Sequence:
MRKIGIIGGTFDPPHYGHLLIANEVYHALNLEEVWFLPNQIPPHKQGRNITSVESRLQMLELATEAEEHFSICLEELSRKGPSYTYDTMLQLTKKYPDVQFHFIIGGDMVEYLPKWYNIEALLDLVTFVGVARPGYKLRTPYPITTVEIPEFAVSSSLLRERYKEKKTCKYLLPEKVQVYIERNGLYES
  
Inhibitor
Name:
BDBM81359
Synonyms:
NadD inhibitor 1_03 | US8785499, 1_03
Type:
Small organic molecule
Emp. Form.:
C26H22BrN3O2
Mol. Mass.:
488.376
SMILES:
Brc1ccc(NC(=O)CCCC(=O)N\N=C\c2c3ccccc3cc3ccccc23)cc1
Structure:
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