Reaction Details Report a problem with these data
Target
Disulfide bond formation protein B
Ligand
BDBM81418
Substrate
n/a
Meas. Tech.
Biochemical Assay
pH
6.2±0
Temperature
303.15±0 K
IC50
1.00e+5±n/a nM
Citation
 Früh, V; Zhou, Y; Chen, D; Loch, C; Ab, E; Grinkova, YN; Verheij, H; Sligar, SG; Bushweller, JH; Siegal, G Application of fragment-based drug discovery to membrane proteins: identification of ligands of the integral membrane enzyme DsbB. Chem Biol 17:881-91 (2010) [PubMed]  Article 
Target
Name:
Disulfide bond formation protein B
Synonyms:
DSBB_ECOLI | Disulfide bond formation protein B (DsbB) | Disulfide oxidoreductase | dsbB | roxB | ycgA
Type:
Protein
Mol. Mass.:
20147.01
Organism:
Escherichia coli
Description:
P0A6M2
Residue:
176
Sequence:
MLRFLNQCSQGRGAWLLMAFTALALELTALWFQHVMLLKPCVLCIYERCALFGVLGAALIGAIAPKTPLRYVAMVIWLYSAFRGVQLTYEHTMLQLYPSPFATCDFMVRFPEWLPLDKWVPQVFVASGDCAERQWDFLGLEMPQWLLGIFIAYLIVAVLVVISQPFKAKKRDLFGR
  
Inhibitor
Name:
BDBM81418
Synonyms:
Fragment 2
Type:
Small organic molecule
Emp. Form.:
C17H20O3
Mol. Mass.:
272.3389
SMILES:
CCC(=O)C1C(=O)CC(C)(C)C(C1=O)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: