Reaction Details Report a problem with these data
Target
HTH-type transcriptional regulator MgrA
Ligand
BDBM11979
Substrate
n/a
Meas. Tech.
Biochemical Assay
pH
7.4±0
Temperature
280.85±0 K
IC50
8e+3±n/a nM
Citation
 Sun, F; Zhou, L; Zhao, BC; Deng, X; Cho, H; Yi, C; Jian, X; Song, CX; Luan, CH; Bae, T; Li, Z; He, C Targeting MgrA-Mediated Virulence Regulation in Staphylococcus aureus. Chem Biol 18:1032-41 (2011) [PubMed]  Article 
Target
Name:
HTH-type transcriptional regulator MgrA
Synonyms:
HTH-type transcriptional regulator mgrA (MgrA) | MGRA_STAAU | Regulator of autolytic activity | mgr | mgrA
Type:
Protein
Mol. Mass.:
17090.77
Organism:
Staphylococcus aureus
Description:
P0C1S0
Residue:
147
Sequence:
MSDQHNLKEQLCFSLYNAQRQVNRYYSNKVFKKYNLTYPQFLVLTILWDESPVNVKKVVTELALDTGTVSPLLKRMEQVDLIKRERSEVDQREVFIHLTDKSETIRPELSNASDKVASASSLSQDEVKELNRLLGKVIHAFDETKEK
  
Inhibitor
Name:
BDBM11979
Synonyms:
5-[(3-carboxy-4-hydroxyphenyl)methyl]-2-hydroxybenzoic acid | CHEMBL115145 | MgrA inhibitor, 1 | chemical diversity library compound 4
Type:
Small organic molecule
Emp. Form.:
C15H12O6
Mol. Mass.:
288.2522
SMILES:
OC(=O)c1cc(Cc2ccc(O)c(c2)C(O)=O)ccc1O
Structure:
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