Reaction Details Report a problem with these data
Target
HTH-type transcriptional regulator MgrA
Ligand
BDBM81554
Substrate
n/a
Meas. Tech.
Biochemical Assay
pH
7.4±0
Temperature
276.75±0 K
IC50
2.8e+4±n/a nM
Citation
 Sun, F; Zhou, L; Zhao, BC; Deng, X; Cho, H; Yi, C; Jian, X; Song, CX; Luan, CH; Bae, T; Li, Z; He, C Targeting MgrA-Mediated Virulence Regulation in Staphylococcus aureus. Chem Biol 18:1032-41 (2011) [PubMed]  Article 
Target
Name:
HTH-type transcriptional regulator MgrA
Synonyms:
HTH-type transcriptional regulator mgrA (MgrA) | MGRA_STAAU | Regulator of autolytic activity | mgr | mgrA
Type:
Protein
Mol. Mass.:
17090.77
Organism:
Staphylococcus aureus
Description:
P0C1S0
Residue:
147
Sequence:
MSDQHNLKEQLCFSLYNAQRQVNRYYSNKVFKKYNLTYPQFLVLTILWDESPVNVKKVVTELALDTGTVSPLLKRMEQVDLIKRERSEVDQREVFIHLTDKSETIRPELSNASDKVASASSLSQDEVKELNRLLGKVIHAFDETKEK
  
Inhibitor
Name:
BDBM81554
Synonyms:
MgrA inhibitor, 3
Type:
Small organic molecule
Emp. Form.:
C18H20N2O2
Mol. Mass.:
296.3636
SMILES:
Cc1ccc(C)n1[C@@H](CC(O)=O)Cc1c[nH]c2ccccc12 |r|
Structure:
Search PDB for entries with ligand similarity: