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Target
Hyaluronidase-1
Ligand
BDBM81868
Substrate
n/a
Meas. Tech.
Morgan-Elson Assay
pH
3.5±0
Temperature
310.15±0 K
IC50
5.668e+4±n/a nM
Citation
 Olgen, S; Kaessler, A; Nebioglu, D; Jose, J New potent indole derivatives as hyaluronidase inhibitors. Chem Biol Drug Des 70:547-51 (2007) [PubMed]  Article 
Target
Name:
Hyaluronidase-1
Synonyms:
HYAL1 | HYAL1_HUMAN | Hyaluronidase | Hyaluronidase-1 | Hyaluronoglucosaminidase-1 | LUCA1
Type:
Protein
Mol. Mass.:
48369.09
Organism:
Homo sapiens (Human)
Description:
Q1279
Residue:
435
Sequence:
MAAHLLPICALFLTLLDMAQGFRGPLLPNRPFTTVWNANTQWCLERHGVDVDVSVFDVVANPGQTFRGPDMTIFYSSQLGTYPYYTPTGEPVFGGLPQNASLIAHLARTFQDILAAIPAPDFSGLAVIDWEAWRPRWAFNWDTKDIYRQRSRALVQAQHPDWPAPQVEAVAQDQFQGAARAWMAGTLQLGRALRPRGLWGFYGFPDCYNYDFLSPNYTGQCPSGIRAQNDQLGWLWGQSRALYPSIYMPAVLEGTGKSQMYVQHRVAEAFRVAVAAGDPNLPVLPYVQIFYDTTNHFLPLDELEHSLGESAAQGAAGVVLWVSWENTRTKESCQAIKEYMDTTLGPFILNVTSGALLCSQALCSGHGRCVRRTSHPKALLLLNPASFSIQLTPGGGPLSLRGALSLEDQAQMAVEFKCRCYPGWQAPWCERKSMW
  
Inhibitor
Name:
BDBM81868
Synonyms:
N-Substituted indole-2- and 3-carboxamide derivative, 18
Type:
Small organic molecule
Emp. Form.:
C23H18F2N2O
Mol. Mass.:
376.3986
SMILES:
Fc1ccc(CNC(=O)c2cn(Cc3ccc(F)cc3)c3ccccc23)cc1
Structure:
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