Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase transforming protein Abl
Ligand
BDBM3003
Substrate
[Val5]-Angiotensin II
Meas. Tech.
Kinase Inhibition Assay
pH
7.5±n/a
Temperature
293.15±n/a K
IC50
>10000±n/a nM
Citation
 Traxler, P; Bold, G; Frei, J; Lang, M; Lydon, N; Mett, H; Buchdunger, E; Meyer, T; Mueller, M; Furet, P Use of a pharmacophore model for the design of EGF-R tyrosine kinase inhibitors: 4-(phenylamino)pyrazolo[3,4-d]pyrimidines. J Med Chem 40:3601-16 (1997) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase transforming protein Abl
Synonyms:
ABL | ABL_MLVAB | Tyrosine-protein kinase V-ABL
Type:
Enzyme
Mol. Mass.:
81895.89
Organism:
Abelson murine leukemia virus
Description:
P00521
Residue:
746
Sequence:
YITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTIYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKRGTRGGAGSMLQAPELPTKTRTCRRAAEQKASPPSLTPKLLRRQVTASPSSGLSHKKEATKGSASGMGTPATAEPAPPSNKVGLSKASSEEMRVRRHKHSSESPGRDKGRLAKLKPAPPPPPACTGKAGKPAQSPSQEAGEAGGPTKTKCTSLAMDAVNTDPTKAGPPGEGLRKPVPPSVPKPQSTAKPPGTPTSPVSTPSTAPAPSPLAGDQQPSSAAFIPLISTRVSLRKTRQPPERIASGTITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLESNLRELQICPATASSGPAATQDFSKLLSSVKEISDIVRR
  
Inhibitor
Name:
BDBM3003
Synonyms:
1,3-diphenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine | 1,3-diphenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine (11) | CHEMBL122243 | pyrazolopyrimidine deriv. 1
Type:
Small organic molecule
Emp. Form.:
C17H13N5
Mol. Mass.:
287.3186
SMILES:
Nc1ncnc2n(nc(-c3ccccc3)c12)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
[Val5]-Angiotensin II
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
2501.86
Organism:
n/a
Description:
n/a
Residue:
23
Sequence:
ASPARGVALTYRVALHISPRPHE