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Target
Tyrosine-protein kinase transforming protein Abl
Ligand
BDBM3031
Substrate
n/a
Meas. Tech.
Kinase Inhibition Assay
IC50
>10000±n/a nM
Citation
 Traxler, P; Bold, G; Frei, J; Lang, M; Lydon, N; Mett, H; Buchdunger, E; Meyer, T; Mueller, M; Furet, P Use of a pharmacophore model for the design of EGF-R tyrosine kinase inhibitors: 4-(phenylamino)pyrazolo[3,4-d]pyrimidines. J Med Chem 40:3601-16 (1997) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase transforming protein Abl
Synonyms:
ABL | ABL_MLVAB | Tyrosine-protein kinase V-ABL
Type:
Enzyme
Mol. Mass.:
81895.89
Organism:
Abelson murine leukemia virus
Description:
P00521
Residue:
746
Sequence:
YITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTIYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKRGTRGGAGSMLQAPELPTKTRTCRRAAEQKASPPSLTPKLLRRQVTASPSSGLSHKKEATKGSASGMGTPATAEPAPPSNKVGLSKASSEEMRVRRHKHSSESPGRDKGRLAKLKPAPPPPPACTGKAGKPAQSPSQEAGEAGGPTKTKCTSLAMDAVNTDPTKAGPPGEGLRKPVPPSVPKPQSTAKPPGTPTSPVSTPSTAPAPSPLAGDQQPSSAAFIPLISTRVSLRKTRQPPERIASGTITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLESNLRELQICPATASSGPAATQDFSKLLSSVKEISDIVRR
  
Inhibitor
Name:
BDBM3031
Synonyms:
3-((3-Chlorophenyl)amino)-4-(benzylamino)-1H-pyrazolo[3,4-d]pyrimidine | 4-(Phenylamino)pyrazolo[3,4-d]pyrimidine deriv. 32 | 4-N-benzyl-3-N-(3-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidine-3,4-diamine
Type:
Small organic molecule
Emp. Form.:
C18H15ClN6
Mol. Mass.:
350.805
SMILES:
Clc1cccc(Nc2[nH]nc3ncnc(NCc4ccccc4)c23)c1
Structure:
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