Reaction Details
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5-hydroxytryptamine receptor 2A
Ligand
BDBM81989
Substrate
n/a
Ki
1000±n/a nM
Comments
PDSP_3143
Citation
Shank, RP; Vaught, JL; Pelley, KA; Setler, PE; McComsey, DF; Maryanoff, BE McN-5652: a highly potent inhibitor of serotonin uptake. J Pharmacol Exp Ther 247:1032-8 (1988) [PubMed] More Info.:
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2A | 5-HT2 | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_RAT | Htr2 | Htr2a | Serotonin Receptor 2A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52852.05
Organism:
Rattus norvegicus (rat)
Description:
Rat cortex membranes 5-HT2A receptors.
Residue:
471
Sequence:
MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYKSSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV
Inhibitor
Name:
BDBM81989
Synonyms:
CAS_68717 | Clovoxamine | NSC_68717
Type:
Small organic molecule
Emp. Form.:
C14H21ClN2O2
Mol. Mass.:
284.782
SMILES:
COCCCCC(=NOCCN)c1ccc(Cl)cc1 |w:7.7|
Structure:
