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Target
cGMP-dependent protein kinase 1
Ligand
BDBM3044
Substrate
n/a
Meas. Tech.
MLCK assay
IC50
>3000±n/a nM
Citation
 Kleinschroth, J; Hartenstein, J; Rudolph, C; Schachtele, C Novel Indolocarbazole protein kinase C inhibitors with improved biochemical and physicochemical properties. Bioorg Med Chem Lett 5:55-60 (1995)    Article 
Target
Name:
cGMP-dependent protein kinase 1
Synonyms:
CGK 1 alpha | KGP1_BOVIN | PRKG1 | PRKG1B | PRKGR1A | PRKGR1B | cGMP-Dependent Protein Kinase | cGMP-dependent protein kinase 1 alpha | cGMP-dependent protein kinase 1, alpha isozyme
Type:
Enzyme
Mol. Mass.:
76413.14
Organism:
Bos taurus (bovine)
Description:
n/a
Residue:
671
Sequence:
MSELEEDFAKILMLKEERIKELEKRLSEKEEEIQELKRKLHKCQSVLPVPSTHIGPRTTRAQGISAEPQTYRSFHDLRQAFRKFTKSERSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGKVNVTREDSPNEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPPPDDNSGWDIDF
  
Inhibitor
Name:
BDBM3044
Synonyms:
3-{7-methoxy-23-methyl-12,14-dioxo-3,13,23-triazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,22}]tricosa-1(16),2(10),4(9),5,7,11(15),17,19,21-nonaen-3-yl}propanenitrile | Indolocarbazole deriv. 3l
Type:
Small organic molecule
Emp. Form.:
C25H18N4O3
Mol. Mass.:
422.4354
SMILES:
COc1ccc2n(CCC#N)c3c(c4C(=O)NC(=O)c4c4c5ccccc5n(C)c34)c2c1
Structure:
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