Target
Carbonic anhydrase 6
Ligand
BDBM50137676
Substrate
n/a
Meas. Tech.
Enzyme Inhbition Assay
pH
7.5±0
Temperature
293.15±0 K
Ki
3.4±0 nM
Citation
 Winum, JYMontero, JLVullo, DSupuran, CT Carbonic anhydrase inhibitors: glycosylsulfanilamides act as subnanomolar inhibitors of the human secreted isoform VI. Chem Biol Drug Des 74:636-9 (2009) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 6
Synonyms:
CA-VI | CA6 | CAH6_HUMAN | Carbonate dehydratase VI | Carbonic Anhydrase VI | Carbonic anhydrase | Carbonic anhydrase 6 | Carbonic anhydrase 6 (CA VI) | Carbonic anhydrase 6 (CA-VI) | Carbonic anhydrase VI (CA VI) | Salivary carbonic anhydrase | Secreted carbonic anhydrase
Type:
Enzyme
Mol. Mass.:
35371.40
Organism:
Homo sapiens (Human)
Description:
P23280
Residue:
308
Sequence:
MRALVLLLSLFLLGGQAQHVSDWTYSEGALDEAHWPQHYPACGGQRQSPINLQRTKVRYNPSLKGLNMTGYETQAGEFPMVNNGHTVQISLPSTMRMTVADGTVYIAQQMHFHWGGASSEISGSEHTVDGIRHVIEIHIVHYNSKYKSYDIAQDAPDGLAVLAAFVEVKNYPENTYYSNFISHLANIKYPGQRTTLTGLDVQDMLPRNLQHYYTYHGSLTTPPCTENVHWFVLADFVKLSRTQVWKLENSLLDHRNKTIHNDYRRTQPLNHRVVESNFPNQEYTLGSEFQFYLHKIEEILDYLRRALN
  
Inhibitor
Name:
BDBM50137676
Synonyms:
4-(3,4,5-Trihydroxy-6-methyl-tetrahydro-pyran-2-ylamino)-benzenesulfonamide | CHEMBL74846 | N-(p-sulfamoylphenyl)-alpha-glycopyranosylamine, 7 | N-(p-sulfamoylphenyl)-alpha-glycopyranosylamine, 8
Type:
Small organic molecule
Emp. Form.:
C12H18N2O6S
Mol. Mass.:
318.346
SMILES:
CC1OC(Nc2ccc(cc2)S(N)(=O)=O)C(O)C(O)C1O
Structure:
Search PDB for entries with ligand similarity: