Reaction Details Report a problem with these data
Target
Platelet-activating factor receptor
Ligand
BDBM82381
Substrate
n/a
Ki
5.48±n/a nM
Comments
PDSP_1054
Citation
 Hwang, SB; Lam, MH; Alberts, AW; Bugianesi, RL; Chabala, JC; Ponpipom, MM Biochemical and pharmacological characterization of L-659,989: an extremely potent, selective and competitive receptor antagonist of platelet-activating factor. J Pharmacol Exp Ther 246:534-41 (1988) [PubMed] 
Target
Name:
Platelet-activating factor receptor
Synonyms:
PAF Platelet activating factor | PAF-R | PAFR | PTAFR | PTAFR_HUMAN | Platelet activating factor receptor | Platelet-activating factor receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39219.60
Organism:
Homo sapiens (Human)
Description:
PAF Platelet activating factor PTAFR HUMAN::P25105
Residue:
342
Sequence:
MEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLTMADMLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRFQAVTRPIKTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGNVTRCFEHYEKGSVPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQPVQQQRNAEVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLTEKFYSMRSSRKCSRATTDTVTEVVVPFNQIPGNSLKN
  
Inhibitor
Name:
BDBM82381
Synonyms:
L-659,989, (-)
Type:
n/a
Emp. Form.:
C24H32O8S
Mol. Mass.:
480.571
SMILES:
CCCOc1c(OC)cc(cc1S(C)(=O)=O)[C@H]1CC[C@@H](O1)c1cc(OC)c(OC)c(OC)c1 |r|
Structure:
Search PDB for entries with ligand similarity: