Reaction Details
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GABA(A) receptor-associated protein
Ligand
BDBM50019260
Substrate
n/a
Ki
3000±n/a nM
Comments
PDSP_45
Citation
Evans, BE; Bock, MG; Rittle, KE; DiPardo, RM; Whitter, WL; Veber, DF; Anderson, PS; Freidinger, RM Design of potent, orally effective, nonpeptidal antagonists of the peptide hormone cholecystokinin. Proc Natl Acad Sci U S A 83:4918-22 (1986) [PubMed] Article More Info.:
Target
Name:
GABA(A) receptor-associated protein
Synonyms:
GABA A Benzodiazepine | GABA-A receptor subunit alpha 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
13921.89
Organism:
GUINEA PIG
Description:
D7RA28
Residue:
117
Sequence:
MKFVYKEEHPFEKRRSEGEKIRKKYPDRVPVIVEKAPKARIGDLDKKKYLVPSDLTVGQFYFLIRKRIHLRAEDALFFFVNNVIPPTSATMGQLYQEHHEEDFFLYIAYSDESVYGL
Inhibitor
Name:
BDBM50019260
Synonyms:
1H-Indole-2-carboxylic acid [5-(2-fluoro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-amide | 1H-Indole-2-carboxylic acid [5-(2-fluoro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-amide: 0.16CH2Cl2 | CCK antagonist synthetic 21 | CHEMBL306806
Type:
Small organic molecule
Emp. Form.:
C24H17FN4O2
Mol. Mass.:
412.4158
SMILES:
Fc1ccccc1C1=NC(NC(=O)c2cc3ccccc3[nH]2)C(=O)Nc2ccccc12 |t:8|
Structure:
