Reaction Details
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G_PROTEIN_RECEP_F1_2 domain-containing protein
Ligand
BDBM21395
Substrate
n/a
Ki
>10000±n/a nM
Comments
PDSP_1014
Citation
Schoeffter, P; Waeber, C 5-Hydroxytryptamine receptors with a 5-HT6 receptor-like profile stimulating adenylyl cyclase activity in pig caudate membranes. Naunyn Schmiedebergs Arch Pharmacol 350:356-60 (1994) [PubMed] Article More Info.:
Target
Name:
G_PROTEIN_RECEP_F1_2 domain-containing protein
Synonyms:
5-HT6 | HTR6
Type:
Enzyme Catalytic Domain
Mol. Mass.:
47273.78
Organism:
PIG
Description:
5-HT6 HTR6 PIG::I3LCE8
Residue:
440
Sequence:
MVLAQGPVNHSTPDWESGPPSEPGGSGWVAAALCVVIALTAAANSLLIVLICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWAAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPPRALALVLSAWSLAALASFLPLLLGWHELGRVRAPAPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTAMTGQALETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIAQAVCDCVSPGLFDGLTWLGYCNSTMNPIIYPLFMRDFKRALGRFMPCPRCPREHQASLASPSMRTSHSGPRPGLSLQHVLPLPLPTNLDLDSDSGTGGSSGPQFTAQLLLPGEAARDPPLPAKATTAVNVFNVDPVEPELRLHPRGSPTN
Inhibitor
Name:
BDBM21395
Synonyms:
3-(2-(4-(4-Fluorobenzoyl)piperidinol)ethyl)-2,4(1H,3H)-quinazolinedione | 3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}ethyl)-1,2,3,4-tetrahydroquinazoline-2,4-dione | CHEMBL1628637 | CHEMBL51 | Ketanserin | R-41,468 | R-41-468 | R41,468 | [3H]-Ketanserin
Type:
radiolabeled ligand
Emp. Form.:
C22H22FN3O3
Mol. Mass.:
395.4268
SMILES:
Fc1ccc(cc1)C(=O)C1CCN(CCn2c(=O)[nH]c3ccccc3c2=O)CC1
Structure:
