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Target
Beta-lactamase
Ligand
BDBM83263
Substrate
n/a
Meas. Tech.
Counterscreen for inhibitors of TLR9-MyD88 binding: fluorescence-based cell-based high throughput dose response assay to identify non-selective inhibitors of the beta-lactamase enzyme (BLA)
IC50
3709±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of TLR9-MyD88 binding: fluorescence-based cell-based high throughput dose response assay to identify non-selective inhibitors of the beta-lactamase enzyme (BLA) PubChem Bioassay (2011)[AID] 
Target
Name:
Beta-lactamase
Synonyms:
Beta lactamase
Type:
Enzyme Catalytic Domain
Mol. Mass.:
31513.38
Organism:
Pseudomonas aeruginosa
Description:
gi_114881106
Residue:
286
Sequence:
MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW
  
Inhibitor
Name:
BDBM83263
Synonyms:
MLS001065937 | N-butyl-2-(4-cyclohexylsulfanylphenyl)imidazo[1,2-a]pyrazin-3-amine | N-butyl-2-[4-(cyclohexylthio)phenyl]-3-imidazo[1,2-a]pyrazinamine | SMR000814582 | butyl-[2-[4-(cyclohexylthio)phenyl]imidazo[1,2-a]pyrazin-3-yl]amine | cid_42601124
Type:
Small organic molecule
Emp. Form.:
C22H28N4S
Mol. Mass.:
380.55
SMILES:
CCCCNc1c(nc2cnccn12)-c1ccc(SC2CCCCC2)cc1
Structure:
Search PDB for entries with ligand similarity: