Reaction Details Report a problem with these data
Target
Phospholipase A2
Ligand
BDBM54430
Substrate
n/a
Meas. Tech.
Dose response counterscreen of uHTS hits for ATG4B inhibitors in a Phospholipase A2 assay
IC50
21200±n/a nM
Citation
 PubChem, PC Dose response counterscreen of uHTS hits for ATG4B inhibitors in a Phospholipase A2 assay PubChem Bioassay (2011)[AID] 
Target
Name:
Phospholipase A2
Synonyms:
Phosphatidylcholine 2-acylhydrolase 1B | phospholipase A2 precursor | Group IB phospholipase A2 | Phospholipase A2 (PLA2) | Phospholipase A2 group 1B | PA21B_HUMAN | PLA2G1B | PLA2 | PLA2A | PPLA2
Type:
Protein
Mol. Mass.:
16364.13
Organism:
Human
Description:
P04054
Residue:
148
Sequence:
MKLLVLAVLLTVAAADSGISPRAVWQFRKMIKCVIPGSDPFLEYNNYGCYCGLGGSGTPVDELDKCCQTHDNCYDQAKKLDSCKFLLDNPYTHTYSYSCSGSAITCSSKNKECEAFICNCDRNAAICFSKAPYNKAHKNLDTKKYCQS
  
Inhibitor
Name:
BDBM54430
Synonyms:
MLS001195390 | cid_1471860 | 2-[(4-methylphenyl)methylsulfanyl]-4-oxo-6-phenyl-1H-pyrimidine-5-carbonitrile | 4-hydroxy-2-[(4-methylbenzyl)sulfanyl]-6-phenyl-5-pyrimidinecarbonitrile | 2-[(4-methylphenyl)methylthio]-4-oxo-6-phenyl-1H-pyrimidine-5-carbonitrile | SMR000550590 | 2-[(4-methylphenyl)methylsulfanyl]-4-oxidanylidene-6-phenyl-1H-pyrimidine-5-carbonitrile | 4-keto-2-[(4-methylbenzyl)thio]-6-phenyl-1H-pyrimidine-5-carbonitrile
Type:
Small organic molecule
Emp. Form.:
C19H15N3OS
Mol. Mass.:
333.09
SMILES:
Cc1ccc(CSc2nc(-c3ccccc3)c(C#N)c(=O)[nH]2)cc1
Structure:
Search PDB for entries with ligand similarity: