Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM51262
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
>99000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM51262
Synonyms:
3-(1-benzofuran-2-carbonyl)-4-hydroxy-2-phenyl-1-(1,3-thiazol-2-yl)-2H-pyrrol-5-one | 3-(1-benzofuran-2-ylcarbonyl)-4-oxidanyl-2-phenyl-1-(1,3-thiazol-2-yl)-2H-pyrrol-5-one | 3-[2-benzofuranyl(oxo)methyl]-4-hydroxy-2-phenyl-1-(2-thiazolyl)-2H-pyrrol-5-one | 4-(Benzofuran-2-carbonyl)-3-hydroxy-5-phenyl-1-thiazol-2-yl-1,5-dihydro-pyrrol-2-one | 4-(benzofuran-2-carbonyl)-3-hydroxy-5-phenyl-1-thiazol-2-yl-3-pyrrolin-2-one | MLS000332351 | SMR000434941 | cid_3830309
Type:
Small organic molecule
Emp. Form.:
C22H14N2O4S
Mol. Mass.:
402.423
SMILES:
O=C(C1C(N(C(=O)C1=O)c1nccs1)c1ccccc1)c1cc2ccccc2o1
Structure:
Search PDB for entries with ligand similarity: