Reaction Details Report a problem with these data
Target
Caspase-9
Ligand
BDBM42221
Substrate
n/a
Meas. Tech.
Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay
IC50
2160±n/a nM
Citation
 PubChem, PC Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay PubChem Bioassay (2011)[AID] 
Target
Name:
Caspase-9
Synonyms:
Apoptotic protease-activating factor 1/Caspase-3/Caspase-9/Cytochrome c | Apoptotic protease-activating factor 3 | CASP-9 | CASP9 | CASP9_HUMAN | Caspase 9 | ICE-like apoptotic protease 6 | MCH6 | caspase-9 isoform alpha preproprotein
Type:
Enzyme
Mol. Mass.:
46277.29
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
416
Sequence:
MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLIIDLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEVLRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS
  
Inhibitor
Name:
BDBM42221
Synonyms:
2-({4-[3-(4-hydroxyphenyl)acryloyl]phenyl}amino)-3-(1-piperidinyl)naphthoquinone | 2-[4-[(E)-3-(4-hydroxyphenyl)-1-oxoprop-2-enyl]anilino]-3-(1-piperidinyl)naphthalene-1,4-dione | 2-[4-[(E)-3-(4-hydroxyphenyl)acryloyl]anilino]-3-piperidino-1,4-naphthoquinone | 2-[4-[(E)-3-(4-hydroxyphenyl)prop-2-enoyl]anilino]-3-piperidin-1-ylnaphthalene-1,4-dione | 2-[[4-[(E)-3-(4-hydroxyphenyl)prop-2-enoyl]phenyl]amino]-3-piperidin-1-yl-naphthalene-1,4-dione | MLS000578787 | SMR000186576 | cid_5341375
Type:
Small organic molecule
Emp. Form.:
C30H26N2O4
Mol. Mass.:
478.5384
SMILES:
Oc1ccc(C=CC(=O)c2ccc(NC3=C(N4CCCCC4)C(=O)c4ccccc4C3=O)cc2)cc1 |w:6.6,c:14|
Structure:
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