Reaction Details Report a problem with these data
Target
Caspase-9
Ligand
BDBM72507
Substrate
n/a
Meas. Tech.
Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay
IC50
10400±n/a nM
Citation
 PubChem, PC Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay PubChem Bioassay (2011)[AID] 
Target
Name:
Caspase-9
Synonyms:
Apoptotic protease-activating factor 1/Caspase-3/Caspase-9/Cytochrome c | Apoptotic protease-activating factor 3 | CASP-9 | CASP9 | CASP9_HUMAN | Caspase 9 | ICE-like apoptotic protease 6 | MCH6 | caspase-9 isoform alpha preproprotein
Type:
Enzyme
Mol. Mass.:
46277.29
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
416
Sequence:
MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLIIDLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEVLRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS
  
Inhibitor
Name:
BDBM72507
Synonyms:
(4-chlorodithiazol-5-ylidene)-(5-chloro-2-pyridyl)amine | 4-chloranyl-N-(5-chloranylpyridin-2-yl)-1,2,3-dithiazol-5-imine | 4-chloro-N-(5-chloro-2-pyridinyl)-5-dithiazolimine | 4-chloro-N-(5-chloropyridin-2-yl)dithiazol-5-imine | MLS000717769 | SMR000279137 | cid_548573
Type:
Small organic molecule
Emp. Form.:
C7H3Cl2N3S2
Mol. Mass.:
264.155
SMILES:
Clc1nss\c1=N/c1ccc(Cl)cn1
Structure:
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