Reaction Details Report a problem with these data
Target
Caspase-9
Ligand
BDBM58062
Substrate
n/a
Meas. Tech.
Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay
IC50
7820±n/a nM
Citation
 PubChem, PC Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay PubChem Bioassay (2011)[AID] 
Target
Name:
Caspase-9
Synonyms:
Apoptotic protease-activating factor 1/Caspase-3/Caspase-9/Cytochrome c | Apoptotic protease-activating factor 3 | CASP-9 | CASP9 | CASP9_HUMAN | Caspase 9 | ICE-like apoptotic protease 6 | MCH6 | caspase-9 isoform alpha preproprotein
Type:
Enzyme
Mol. Mass.:
46277.29
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
416
Sequence:
MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLIIDLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEVLRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS
  
Inhibitor
Name:
BDBM58062
Synonyms:
(3Z)-3-(4-bromophenyl)sulfonylimino-2-[3-(3-methylbutyl)-1-imidazol-3-iumyl]-4-oxo-1-naphthalenolate | (3Z)-3-(4-bromophenyl)sulfonylimino-2-[3-(3-methylbutyl)imidazol-3-ium-1-yl]-4-oxidanylidene-naphthalen-1-olate | (3Z)-3-(4-bromophenyl)sulfonylimino-2-[3-(3-methylbutyl)imidazol-3-ium-1-yl]-4-oxonaphthalen-1-olate | (3Z)-3-brosylimino-2-(3-isoamylimidazol-3-ium-1-yl)-4-keto-naphthalen-1-olate | MLS000768822 | SMR000432128 | cid_16411432
Type:
Small organic molecule
Emp. Form.:
C24H22BrN3O4S
Mol. Mass.:
528.418
SMILES:
CC(C)CC[n+]1ccn(c1)C1=C([N-]S(=O)(=O)c2ccc(Br)cc2)C(=O)c2ccccc2C1=O |c:11|
Structure:
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