Reaction Details Report a problem with these data
Target
Caspase-9
Ligand
BDBM83992
Substrate
n/a
Meas. Tech.
Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay
IC50
2220±n/a nM
Citation
 PubChem, PC Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay PubChem Bioassay (2011)[AID] 
Target
Name:
Caspase-9
Synonyms:
Apoptotic protease-activating factor 1/Caspase-3/Caspase-9/Cytochrome c | Apoptotic protease-activating factor 3 | CASP-9 | CASP9 | CASP9_HUMAN | Caspase 9 | ICE-like apoptotic protease 6 | MCH6 | caspase-9 isoform alpha preproprotein
Type:
Enzyme
Mol. Mass.:
46277.29
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
416
Sequence:
MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLIIDLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEVLRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS
  
Inhibitor
Name:
BDBM83992
Synonyms:
(2R)-2-[[7-(benzylamino)-3-isopropyl-benzimidazol-5-yl]amino]propan-1-ol | (2R)-2-[[7-(benzylamino)-3-propan-2-ylbenzimidazol-5-yl]amino]propan-1-ol | (2R)-2-[[7-[(phenylmethyl)amino]-3-propan-2-yl-5-benzimidazolyl]amino]-1-propanol | (2R)-2-[[7-[(phenylmethyl)amino]-3-propan-2-yl-benzimidazol-5-yl]amino]propan-1-ol | MLS002471441 | SMR001395107 | cid_44143082
Type:
Small organic molecule
Emp. Form.:
C20H26N4O
Mol. Mass.:
338.4466
SMILES:
C[C@H](CO)Nc1cc(NCc2ccccc2)c2ncn(C(C)C)c2c1
Structure:
Search PDB for entries with ligand similarity: