Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83576
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule activators of the MazEF TA System via a fluorescence-based single-stranded RNase assay
EC50
>99000±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule activators of the MazEF TA System via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83576
Synonyms:
4-fluoranyl-N-[[4-thiophen-2-yl-6-(trifluoromethyl)pyrimidin-2-yl]carbamoyl]benzamide | 4-fluoro-N-({[4-thien-2-yl-6-(trifluoromethyl)pyrimidin-2-yl]amino}carbonyl)benzamide | 4-fluoro-N-[[4-(2-thienyl)-6-(trifluoromethyl)pyrimidin-2-yl]carbamoyl]benzamide | 4-fluoro-N-[[4-thiophen-2-yl-6-(trifluoromethyl)pyrimidin-2-yl]carbamoyl]benzamide | 4-fluoro-N-[oxo-[[4-thiophen-2-yl-6-(trifluoromethyl)-2-pyrimidinyl]amino]methyl]benzamide | MLS000586741 | SMR000208672 | cid_1263771
Type:
Small organic molecule
Emp. Form.:
C17H10F4N4O2S
Mol. Mass.:
410.346
SMILES:
Fc1ccc(cc1)C(=O)NC(=O)Nc1nc(cc(n1)C(F)(F)F)-c1cccs1
Structure:
Search PDB for entries with ligand similarity: