Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83648
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule activators of the MazEF TA System via a fluorescence-based single-stranded RNase assay
EC50
17700±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule activators of the MazEF TA System via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83648
Synonyms:
2-(4-chlorophenyl)ethyl-(8-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-4-yl)amine | MLS001199781 | N-[2-(4-chlorophenyl)ethyl]-8-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-4-amine | N-[2-(4-chlorophenyl)ethyl]-8-methyl[1,2,4]triazolo[4,3-a]quinoxalin-4-amine | SMR000560085 | cid_15989752
Type:
Small organic molecule
Emp. Form.:
C18H16ClN5
Mol. Mass.:
337.806
SMILES:
Cc1ccc2nc(NCCc3ccc(Cl)cc3)c3nncn3c2c1
Structure:
Search PDB for entries with ligand similarity: