Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83496
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule activators of the MazEF TA System via a fluorescence-based single-stranded RNase assay
EC50
19300±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule activators of the MazEF TA System via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83496
Synonyms:
3-[4-(1-azepanylsulfonyl)anilino]-2-(2-pyridinyl)-3H-isoindol-1-one | 3-[4-(azepan-1-ylsulfonyl)anilino]-2-(2-pyridyl)isoindolin-1-one | 3-[4-(azepan-1-ylsulfonyl)anilino]-2-pyridin-2-yl-3H-isoindol-1-one | 3-[[4-(azepan-1-ylsulfonyl)phenyl]amino]-2-pyridin-2-yl-3H-isoindol-1-one | MLS000522898 | SMR000128164 | cid_9550095
Type:
Small organic molecule
Emp. Form.:
C25H26N4O3S
Mol. Mass.:
462.564
SMILES:
O=C1N(C(Nc2ccc(cc2)S(=O)(=O)N2CCCCCC2)c2ccccc12)c1ccccn1
Structure:
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