Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM75974
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule activators of the MazEF TA System via a fluorescence-based single-stranded RNase assay
EC50
29100±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule activators of the MazEF TA System via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM75974
Synonyms:
2-(2-Phenyl-quinazolin-4-ylsulfanyl)-N-thiazol-2-yl-acetamide | 2-(2-phenylquinazolin-4-yl)sulfanyl-N-(1,3-thiazol-2-yl)acetamide | 2-(2-phenylquinazolin-4-yl)sulfanyl-N-(1,3-thiazol-2-yl)ethanamide | 2-[(2-phenyl-4-quinazolinyl)thio]-N-(2-thiazolyl)acetamide | 2-[(2-phenylquinazolin-4-yl)thio]-N-thiazol-2-yl-acetamide | MLS000552333 | SMR000178111 | cid_1072346
Type:
Small organic molecule
Emp. Form.:
C19H14N4OS2
Mol. Mass.:
378.471
SMILES:
O=C(CSc1nc(nc2ccccc12)-c1ccccc1)Nc1nccs1
Structure:
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