Reaction Details Report a problem with these data
Target
Multidrug efflux pump
Ligand
BDBM64568
Substrate
n/a
Meas. Tech.
Dose Response HTS singleplex for inhibitors of yeast efflux pump, specifically Mdr1 with Hit compounds from Cherry Pick1
EC50
7760±n/a nM
Citation
 PubChem, PC Dose Response HTS singleplex for inhibitors of yeast efflux pump, specifically Mdr1 with Hit compounds from Cherry Pick1 PubChem Bioassay (2011)[AID] 
Target
Name:
Multidrug efflux pump
Synonyms:
Candida albicans strain ATCC 10261 multidrug efflux pump (MDR1) gene, MDR1-A allele, complete cds
Type:
Enzyme Catalytic Domain
Mol. Mass.:
62915.82
Organism:
Candida albicans
Description:
Q09GR2
Residue:
564
Sequence:
MHYRFLRDSFVGRVTYHLSKHKYFAHPEEAKDYIVPEKYLADYKPTLADDTSINFEKEEIDNQGEPNSSQSSSSNNTIVDNNNNNDNDVDGDKIVVTWDGDDDPENPQNWPTLQKAFFIFQISFLTTSVYMGSAVYTPGIEELMHDFGIGRVVATLPLTLFVIGYGVGPLVFSPMSENAIFGRTSIYIITLFLFVILQIPTALVNNIAGLCILRFLGGFFASPCLATGGASVADVVKFWNLPVGLAAWSLGAVCGPSFGPFFGSILTVKASWRWTFWFMCIISGFSFVMLCFTLPETFGKTLLYRKAKRLRAITGNDRITSEGEIENSKMTSHELIIDTLWRPLEITVMEPVVLLINIYIAMVYSILYLFFEVFPIYFVGVKHFTLVELGTTYMSIVIGIVIAAFIYIPVIRQKFTKPILRQEQVFPEVFIPIAIVGGILLTSGLFIFGWSANRTTHWVGPLFGAATTASGAFLIFQTLFNFMGASFKPHYIASVFASNDLFRSVIASVFPLFGAPLFDNLATPEYPVAWGSSVLGFITLVMIAIPVLFYLNGPKLRARSKYAN
  
Inhibitor
Name:
BDBM64568
Synonyms:
1-methyl-3-[(1-methyl-3-indolyl)-(2-pyridinyl)methyl]indole | 1-methyl-3-[(1-methylindol-3-yl)-(2-pyridyl)methyl]indole | 1-methyl-3-[(1-methylindol-3-yl)-pyridin-2-yl-methyl]indole | 1-methyl-3-[(1-methylindol-3-yl)-pyridin-2-ylmethyl]indole | 3,3'-(2-pyridinylmethylene)bis(1-methyl-1H-indole) | MLS000535502 | SMR000142937 | cid_2948951
Type:
Small organic molecule
Emp. Form.:
C24H21N3
Mol. Mass.:
351.4436
SMILES:
Cn1cc(C(c2cn(C)c3ccccc23)c2ccccn2)c2ccccc12
Structure:
Search PDB for entries with ligand similarity: