Reaction Details Report a problem with these data
Target
Potassium voltage-gated channel subfamily KQT member 2
Ligand
BDBM84159
Substrate
n/a
Meas. Tech.
Dose response assay for compounds that inhibit KCNQ2 potassium channels on automated electrophysiological assay II
IC50
513.39±107.66 nM
Citation
 PubChem, PC Dose response assay for compounds that inhibit KCNQ2 potassium channels on automated electrophysiological assay II PubChem Bioassay (2011)[AID] 
Target
Name:
Potassium voltage-gated channel subfamily KQT member 2
Synonyms:
KCNQ2_RAT | Kcnq2 | Voltage-gated potassium channel subunit Kv7.2 | potassium voltage-gated channel, KQT-like subfamily, member 2
Type:
PROTEIN
Mol. Mass.:
93984.01
Organism:
Rattus norvegicus
Description:
EBI_100117
Residue:
852
Sequence:
MVQKSRNGGVYPGTSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSVLSKPRTGGAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTWQYYERTVTVPMISSQTQTYGASRLIPPLNQLEMLRNLKSKSGLTFRKEPQPEPSPSQKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLDDSPSKVPKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVEDNKSCNCEFVTEDLTPGLKVSIRAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRVDQIVGRGPTITDKDRTKGPAETELPEDPSMMGRLGKVEKQVLSMEKKLDFLVSIYTQRMGIPPAETEAYFGAKEPEPAPPYHSPEDSRDHADKHGCIIKIVRSTSSTGQRKYAAPPVMPPAECPPSTSWQQSHQRHGTSPVGDHGSLVRIPPPPAHERSLSAYSGGNRASTEFLRLEGTPACRPSEAALRDSDTSISIPSVDHEELERSFSGFSISQSKENLNALASCYAAVAPCAKVRPYIAEGESDTDSDLCTPCGPPPRSATGEGPFGDVAWAGPRK
  
Inhibitor
Name:
BDBM84159
Synonyms:
MLS000520753 | N-(4-oxidanylidene-2-phenacylsulfanyl-quinazolin-3-yl)benzamide | N-(4-oxo-2-phenacylsulfanylquinazolin-3-yl)benzamide | N-[4-keto-2-(phenacylthio)quinazolin-3-yl]benzamide | N-[4-oxo-2-(phenacylthio)-3-quinazolinyl]benzamide | SMR000131162 | cid_4444272
Type:
Small organic molecule
Emp. Form.:
C23H17N3O3S
Mol. Mass.:
415.464
SMILES:
O=C(CSc1nc2ccccc2c(=O)n1NC(=O)c1ccccc1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: