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Target
Cyclin-dependent kinase 1
Ligand
BDBM7262
Substrate
n/a
Meas. Tech.
Kinase Assay
pH
7.5±0
Temperature
303.15±0 K
IC50
35±0.0 nM
Citation
Kunick, C; Zeng, Z; Gussio, R; Zaharevitz, D; Leost, M; Totzke, F; Schächtele, C; Kubbutat, MH; Meijer, L; Lemcke, T Structure-aided optimization of kinase inhibitors derived from alsterpaullone. Chembiochem 6:541-9 (2005) [PubMed] Article
More Info.:
Target
Name:
Cyclin-dependent kinase 1
Synonyms:
CDC2 | CDC28A | CDK1 | CDK1_HUMAN | CDKN1 | Cell division control protein 2 homolog | Cell division protein kinase 1 | Cyclin-dependent kinase 1 (CDK1) | P34CDC2 | p34 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
34101.08
Organism:
Homo sapiens (Human)
Description:
P06493
Residue:
297
Sequence:
MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
Inhibitor
Name:
BDBM7262
Synonyms:
14-nitro-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,17}]octadeca-1(11),2,4,6,12(17),13,15-heptaen-9-one | 9-Nitropaullone | BDBM84528 | CHEMBL50894 | NSC 705701 | Paullone Analog 1 | alsterpaullone
Type:
Small organic molecule
Emp. Form.:
C16H11N3O3
Mol. Mass.:
293.2768
SMILES:
[O-][N+](=O)c1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1