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Target
Cyclin-dependent kinase 1
Ligand
BDBM84531
Substrate
n/a
Meas. Tech.
Kinase Assay
pH
7.5±0
Temperature
303.15±0 K
IC50
25±0.0 nM
Citation
 Kunick, C; Zeng, Z; Gussio, R; Zaharevitz, D; Leost, M; Totzke, F; Schächtele, C; Kubbutat, MH; Meijer, L; Lemcke, T Structure-aided optimization of kinase inhibitors derived from alsterpaullone. Chembiochem 6:541-9 (2005) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 1
Synonyms:
CDC2 | CDC28A | CDK1 | CDK1_HUMAN | CDKN1 | Cell division control protein 2 homolog | Cell division protein kinase 1 | Cyclin-dependent kinase 1 (CDK1) | P34CDC2 | p34 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
34101.08
Organism:
Homo sapiens (Human)
Description:
P06493
Residue:
297
Sequence:
MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
  
Inhibitor
Name:
BDBM84531
Synonyms:
Alsterpaullone derivative, 5
Type:
Small organic molecule
Emp. Form.:
C19H15N3O5
Mol. Mass.:
365.3395
SMILES:
OC(=O)CCc1ccc2NC(=O)Cc3c([nH]c4ccc(cc34)[N+]([O-])=O)-c2c1
Structure:
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