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Target
Cyclin-dependent kinase 2
Ligand
BDBM54680
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
8±0
Temperature
295.15±0 K
IC50
1e+3±n/a nM
Citation
 Jautelat, R; Brumby, T; Schäfer, M; Briem, H; Eisenbrand, G; Schwahn, S; Krüger, M; Lücking, U; Prien, O; Siemeister, G From the insoluble dye indirubin towards highly active, soluble CDK2-inhibitors. Chembiochem 6:531-40 (2005) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM54680
Synonyms:
(3Z)-5-bromanyl-3-(3-oxidanylidene-1H-indol-2-ylidene)-1H-indol-2-one | (3Z)-5-bromo-3-(3-ketoindolin-2-ylidene)oxindole | (3Z)-5-bromo-3-(3-oxo-1H-indol-2-ylidene)-1H-indol-2-one | UNM-0000305770 | cid_5287845
Type:
Small organic molecule
Emp. Form.:
C16H9BrN2O2
Mol. Mass.:
341.159
SMILES:
Brc1ccc2NC(=O)C(=C3Nc4ccccc4C3=O)c2c1 |w:8.20|
Structure:
Search PDB for entries with ligand similarity: