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Target
Bromodomain-containing protein 4 [44-477]
Ligand
BDBM274222
Substrate
n/a
Meas. Tech.
TR-FRET In-Vitro Binding Assay
pH
7.5±n/a
IC50
<11.0±n/a nM
Comments
extracted
Citation
 Rueger, H; Blank, J; Bordas, V; Cotesta, S; Bold, G; Guagnano, V; Vaupel, A Pyrrolopyrrolone derivatives and their use as BET inhibitors US Patent  US9550796 Publication Date 1/24/2017 
Target
Name:
Bromodomain-containing protein 4 [44-477]
Synonyms:
BRD4 | BRD4_HUMAN | Bromodomain-containing protein 4 | HUNK1
Type:
Enzyme Catalytic Domain (aa 44-477)
Mol. Mass.:
48692.13
Organism:
Homo sapiens (Human)
Description:
O60885[44-477]
Residue:
434
Sequence:
NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETEIMIVQAKGRGRGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMTVVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTTIDPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKKDVPDSQQHPAPEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPPPT
  
Inhibitor
Name:
BDBM274222
Synonyms:
1-(1-acetylazetidin-3-yl)-6-(4-chlorophenyl)-3-cyclopropyl-5-(3,8-dimethyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-5,6-dihydropyrrolo[3,4-b]pyrrol-4(1H)-one | US9550796, Example 17
Type:
Small organic molecule
Emp. Form.:
C28H27ClN6O2
Mol. Mass.:
515.006
SMILES:
CC(=O)N1CC(C1)n1cc(C2CC2)c2C(=O)N(C(c12)c1ccc(Cl)cc1)c1cc(C)c2nnc(C)n2c1
Structure:
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