Reaction Details
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Potassium voltage-gated channel subfamily A member 5
Ligand
BDBM50239227
Substrate
n/a
Meas. Tech.
ChEMBL_1665700 (CHEMBL4015496)
IC50
46±n/a nM
Citation
Gunaga, P; Lloyd, J; Mummadi, S; Banerjee, A; Dhondi, NK; Hennan, J; Subray, V; Jayaram, R; Rajugowda, N; Umamaheshwar Reddy, K; Kumaraguru, D; Mandal, U; Beldona, D; Adisechen, AK; Yadav, N; Warrier, J; Johnson, JA; Sale, H; Putlur, SP; Saxena, A; Chimalakonda, A; Mandlekar, S; Conder, M; Xing, D; Gupta, AK; Gupta, A; Rampulla, R; Mathur, A; Levesque, P; Wexler, RR; Finlay, HJ Selective I J Med Chem 60:3795-3803 (2017) [PubMed] Article More Info.:
Target
Name:
Potassium voltage-gated channel subfamily A member 5
Synonyms:
HK2 | HPCN1 | KCNA5 | KCNA5_HUMAN | Potassium voltage-gated channel subfamily A member 5 | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv1.5
Type:
Enzyme
Mol. Mass.:
67222.47
Organism:
Homo sapiens (Human)
Description:
P22460
Residue:
613
Sequence:
MEIALVPLENGGAMTVRGGDEARAGCGQATGGELQCPPTAGLSDGPKEPAPKGRGAQRDADSGVRPLPPLPDPGVRPLPPLPEELPRPRRPPPEDEEEEGDPGLGTVEDQALGTASLHHQRVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDGILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPLPRNEFQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPAPHQPPAPAPGANGSGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAGFSRNIMNIIDVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEPAVLKEEQGTQSQGPGLDRGVQRKVSGSRGSFCKAGGTLENADSARRGSCPLEKCNVKAKSNVDLRRSLYALCLDTSRETDL
Inhibitor
Name:
BDBM50239227
Synonyms:
CHEMBL4094440 | US10214511, Example 7 | US10676460, Example 7
Type:
Small organic molecule
Emp. Form.:
C25H20N6O2S
Mol. Mass.:
468.53
SMILES:
NS(=O)(=O)c1cncc(c1)-c1nc(NCc2ccccn2)c2c(cccc2n1)-c1ccccc1
Structure:
