Reaction Details
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dCTP pyrophosphatase 1
Ligand
BDBM50239517
Substrate
n/a
Meas. Tech.
ChEMBL_1666223 (CHEMBL4016019)
IC50
25±n/a nM
Citation
Llona-Minguez, S; Höglund, A; Ghassemian, A; Desroses, M; Calderón-Montaño, JM; Burgos Morón, E; Valerie, NCK; Wiita, E; Almlöf, I; Koolmeister, T; Mateus, A; Cazares-Körner, C; Sanjiv, K; Homan, E; Loseva, O; Baranczewski, P; Darabi, M; Mehdizadeh, A; Fayezi, S; Jemth, AS; Warpman Berglund, U; Sigmundsson, K; Lundbäck, T; Jenmalm Jensen, A; Artursson, P; Scobie, M; Helleday, T Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors. J Med Chem 60:4279-4292 (2017) [PubMed] Article More Info.:
Target
Name:
dCTP pyrophosphatase 1
Synonyms:
DCTP1_HUMAN | DCTPP1 | Deoxycytidine-triphosphatase 1 | XTP3TPA | dCTP pyrophosphatase 1 | dCTP pyrophosphatase 1 (DCTPP1)
Type:
Protein
Mol. Mass.:
18673.58
Organism:
Homo sapiens (Human)
Description:
Q9H773
Residue:
170
Sequence:
MSVAGGEIRGDTGGEDTAAPGRFSFSPEPTLEDIRRLHAEFAAERDWEQFHQPRNLLLALVGEVGELAELFQWKTDGEPGPQGWSPRERAALQEELSDVLIYLVALAARCRVDLPLAVLSKMDINRRRYPAHLARSSSRKYTELPHGAISEDQAVGPADIPCDSTGQTST
Inhibitor
Name:
BDBM50239517
Synonyms:
CHEMBL4082508
Type:
Small organic molecule
Emp. Form.:
C21H20ClFN6O3S
Mol. Mass.:
490.938
SMILES:
Fc1ccc(CNC(=O)c2ccc(nn2)N2CCN(CC2)S(=O)(=O)c2cccnc2Cl)cc1
Structure:
