Reaction Details Report a problem with these data
Target
Neuromedin-U receptor 1
Ligand
BDBM50239756
Substrate
n/a
Meas. Tech.
ChEMBL_1666878 (CHEMBL4016674)
EC50
8.9±n/a nM
Citation
 Takayama, K; Mori, K; Tanaka, A; Nomura, E; Sohma, Y; Mori, M; Taguchi, A; Taniguchi, A; Sakane, T; Yamamoto, A; Minamino, N; Miyazato, M; Kangawa, K; Hayashi, Y Discovery of a Human Neuromedin U Receptor 1-Selective Hexapeptide Agonist with Enhanced Serum Stability. J Med Chem 60:5228-5234 (2017) [PubMed]  Article 
Target
Name:
Neuromedin-U receptor 1
Synonyms:
G-protein coupled receptor 66 | G-protein coupled receptor FM-3 | Gpr66 | NMU-R1 | NMUR1_MOUSE | Nmur1
Type:
n/a
Mol. Mass.:
47951.94
Organism:
Mus musculus
Description:
n/a
Residue:
428
Sequence:
MTPPCLNCSIFPGALSPNASRSPLVCNISEFKWPYQPEDLNLTDEALRLKYLGPQQMKQFVPICVTYLLIFVVGTLGNGLTCTVILRNKTMRTPTNFYLFSLAVSDMLVLLVGLPLELYEMQQNYPFQLGASACYFRILLLETVCLASVLNVTALSVERYVAVVRPLQAKSVMTRAHVRRMVGAIWVLATLFSLPNTSLHGLSQLTVPCRGPVPDSAICSLVGPMDFYKLVVLTTALLFFCLPMVTISVLYLLIGLRLRRERMLLQVEVKGRKTAATQETSHRRIQLQDRGRRQVTKMLFALVVVFGICWAPFHADRIMWSLVYGHSTEGLHLAYQCVHIASGIFFYLGSAANPVLYSLMSTRFRETFLQALGLGTQCCHRRQPYHGSHNHIRLTTGSTLCDVGHRNSRDEPLAVNEDPGCQQETDPS
  
Inhibitor
Name:
BDBM50239756
Synonyms:
CHEMBL4105671
Type:
Small organic molecule
Emp. Form.:
C46H59N13O7S
Mol. Mass.:
938.109
SMILES:
C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)Cc1cccs1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O |r|
Structure:
Search PDB for entries with ligand similarity: