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Target
Prolyl 4-hydroxylase subunit alpha-1
Ligand
BDBM26114
Substrate
n/a
Meas. Tech.
ChEBML_157461
Ki
800±n/a nM
Citation
 Cunliffe, CJ; Franklin, TJ; Hales, NJ; Hill, GB Novel inhibitors of prolyl 4-hydroxylase. 3. Inhibition by the substrate analogue N-oxaloglycine and its derivatives. J Med Chem 35:2652-8 (1992) [PubMed]  Article 
Target
Name:
Prolyl 4-hydroxylase subunit alpha-1
Synonyms:
P4HA1_RAT | P4ha | P4ha1 | Prolyl 4-hydroxylase alpha-1 subunit
Type:
PROTEIN
Mol. Mass.:
60891.28
Organism:
Rattus norvegicus
Description:
ChEMBL_157460
Residue:
534
Sequence:
MIWGVLMMGILLPQCSAHPGFFTSIGQMTDLIHNEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDRLTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLILKDMSDGFISNLTIQRQYFPNDEDQVGAAKALFRLQDTYNLDTNTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADYYHTELWMEQALMQLEEGEMSTVDKVSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQRANGNLVYFEYIMSKEKDANKSASGDQSDQKTTPKKKGIAVDYLPERQKYEMLCRGEGIKMTPRRQKRLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRLSRATVHDPETGKLTTAQYRVSKSAWLSGYEDPVVSRINMRIQDLTGLDVSTAEELQVANYGVGGQYEPHFDFARKDEPDAFRELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKGTAVFWYNLFASGEGDYSTRHAACPVLVGNKWVSNKWLHERGQEFRRPCTLSELE
  
Inhibitor
Name:
BDBM26114
Synonyms:
CHEMBL88972 | pyridine carboxylate, 6b | pyridine-2,5-dicarboxylic acid
Type:
Small organic molecule
Emp. Form.:
C7H5NO4
Mol. Mass.:
167.1189
SMILES:
OC(=O)c1ccc(nc1)C(O)=O
Structure:
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