Reaction Details Report a problem with these data
Target
ELAV-like protein 1
Ligand
BDBM61111
Substrate
n/a
Meas. Tech.
ChEMBL_1668503 (CHEMBL4018391)
IC50
6700±n/a nM
Citation
 Nasti, R; Rossi, D; Amadio, M; Pascale, A; Unver, MY; Hirsch, AKH; Collina, S Compounds Interfering with Embryonic Lethal Abnormal Vision (ELAV) Protein-RNA Complexes: An Avenue for Discovering New Drugs. J Med Chem 60:8257-8267 (2017) [PubMed]  Article 
Target
Name:
ELAV-like protein 1
Synonyms:
ELAV1_HUMAN | ELAVL1 | HUR | Hu-antigen R
Type:
PROTEIN
Mol. Mass.:
36102.56
Organism:
Homo sapiens (Human)
Description:
ChEMBL_654855
Residue:
326
Sequence:
MSNGYEDHMAEDCRGDIGRTNLIVNYLPQNMTQDELRSLFSSIGEVESAKLIRDKVAGHSLGYGFVNYVTAKDAERAINTLNGLRLQSKTIKVSYARPSSEVIKDANLYISGLPRTMTQKDVEDMFSRFGRIINSRVLVDQTTGLSRGVAFIRFDKRSEAEEAITSFNGHKPPGSSEPITVKFAANPNQNKNVALLSQLYHSPARRFGGPVHHQAQRFRFSPMGVDHMSGLSGVNVPGNASSGWCIFIYNLGQDADEGILWQMFGPFGAVTNVKVIRDFNTNKCKGFGFVTMTNYEEAAMAIASLNGYRLGDKILQVSFKTNKSHK
  
Inhibitor
Name:
BDBM61111
Synonyms:
5,7-dimethoxy-8-[3-oxidanylidene-3-pyrrolidin-1-yl-1-(3,4,5-trimethoxyphenyl)propyl]-4-phenyl-chromen-2-one | 5,7-dimethoxy-8-[3-oxo-3-(1-pyrrolidinyl)-1-(3,4,5-trimethoxyphenyl)propyl]-4-phenyl-1-benzopyran-2-one | 5,7-dimethoxy-8-[3-oxo-3-pyrrolidin-1-yl-1-(3,4,5-trimethoxyphenyl)propyl]-4-phenylchromen-2-one | 8-[3-keto-3-pyrrolidino-1-(3,4,5-trimethoxyphenyl)propyl]-5,7-dimethoxy-4-phenyl-coumarin | MLS000879490 | SMR000465536 | cid_16746465
Type:
Small organic molecule
Emp. Form.:
C33H35NO8
Mol. Mass.:
573.6329
SMILES:
COc1cc(cc(OC)c1OC)C(CC(=O)N1CCCC1)c1c(OC)cc(OC)c2c(cc(=O)oc12)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: