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Target
Adenosine receptor A3
Ligand
BDBM50116368
Substrate
n/a
Meas. Tech.
ChEMBL_1669078 (CHEMBL4018966)
Ki
3.2±n/a nM
Citation
 Xia, L; Burger, WAC; van Veldhoven, JPD; Kuiper, BJ; van Duijl, TT; Lenselink, EB; Paasman, E; Heitman, LH; IJzerman, AP Structure-Affinity Relationships and Structure-Kinetics Relationships of Pyrido[2,1-f]purine-2,4-dione Derivatives as Human Adenosine A J Med Chem 60:7555-7568 (2017) [PubMed]  Article 
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM50116368
Synonyms:
1-Benzyl-7-methoxy-3-propyl-1H-1,3,4b,9-tetraaza-fluorene-2,4-dione | CHEMBL113634
Type:
Small organic molecule
Emp. Form.:
C20H20N4O3
Mol. Mass.:
364.3978
SMILES:
CCCn1c(=O)n(Cc2ccccc2)c2nc3cc(OC)ccn3c2c1=O
Structure:
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