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Target
Sialidase A
Ligand
BDBM50242961
Substrate
n/a
Meas. Tech.
ChEMBL_1672427 (CHEMBL4022456)
IC50
44200±n/a nM
Citation
 Park, JY; Hwan Lim, S; Ram Kim, B; Jae Jeong, H; Kwon, HJ; Song, GY; Bae Ryu, Y; Song Lee, W Sialidase inhibitory activity of diarylnonanoid and neolignan compounds extracted from the seeds of Myristica fragrans. Bioorg Med Chem Lett 27:3060-3064 (2017) [PubMed]  Article 
Target
Name:
Sialidase A
Synonyms:
NANA_STREE | Neuraminidase A (NanA) | Sialidase A | nanA
Type:
Enzyme
Mol. Mass.:
114737.08
Organism:
Streptococcus pneumoniae
Description:
P62576; spr1536
Residue:
1035
Sequence:
MSYFRNRDIDIERNSMNRSVQERKCRYSIRKLSVGAVSMIVGAVVFGTSPVLAQEGASEQPLANETQLSGESSTLTDTEKSQPSSETELSGNKQEQERKDKQEEKIPRDYYARDLENVETVIEKEDVETNASNGQRVDLSSELDKLKKLENATVHMEFKPDAKAPAFYNLFSVSSATKKDEYFTMAVYNNTATLEGRGSDGKQFYNNYNDAPLKVKPGQWNSVTFTVEKPTAELPKGRVRLYVNGVLSRTSLRSGNFIKDMPDVTHVQIGATKRANNTVWGSNLQIRNLTVYNRALTPEEVQKRSQLFKRSDLEKKLPEGAALTEKTDIFESGRNGKPNKDGIKSYRIPALLKTDKGTLIAGADERRLHSSDWGDIGMVIRRSEDNGKTWGDRVTITNLRDNPKASDPSIGSPVNIDMVLVQDPETKRIFSIYDMFPEGKGIFGMSSQKEEAYKKIDGKTYQILYREGEKGAYTIRENGTVYTPDGKATDYRVVVDPVKPAYSDKGDLYKGNQLLGNIYFTTNKTSPFRIAKDSYLWMSYSDDDGKTWSAPQDITPMVKADWMKFLGVGPGTGIVLRNGPHKGRILIPVYTTNNVSHLNGSQSSRIIYSDDHGKTWHAGEAVNDNRQVDGQKIHSSTMNNRRAQNTESTVVQLNNGDVKLFMRGLTGDLQVATSKDGGVTWEKDIKRYPQVKDVYVQMSAIHTMHEGKEYIILSNAGGPKRENGMVHLARVEENGELTWLKHNPIQKGEFAYNSLQELGNGEYGILYEHTEKGQNAYTLSFRKFNWDFLSKDLISPTEAKVKRTREMGKGVIGLEFDSEVLVNKAPTLQLANGKTARFMTQYDTKTLLFTVDSEDMGQKVTGLAEGAIESMHNLPVSVAGTKLSNGMNGSEAAVHEVPEYTGPLGTSGEEPAPTVEKPEYTGPLGTSGEEPAPTVEKPEYTGPLGTAGEEAAPTVEKPEFTGGVNGTEPAVHEIAEYKGSDSLVTLTTKEDYTYKAPLAQQALPETGNKESDLLASLGLTAFFLGLFTLGKKREQ
  
Inhibitor
Name:
BDBM50242961
Synonyms:
CHEMBL4091275
Type:
Small organic molecule
Emp. Form.:
C21H22O5
Mol. Mass.:
354.3964
SMILES:
COc1cc(cc2OCOc12)[C@H]1Oc2c(cc(\C=C\C)cc2OC)[C@@H]1C |r|
Structure:
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