Reaction Details Report a problem with these data
Target
Type-1 angiotensin II receptor
Ligand
BDBM50003385
Substrate
n/a
Meas. Tech.
ChEBML_36783
IC50
6300±n/a nM
Citation
 Bradbury, RH; Allott, CP; Dennis, M; Fisher, E; Major, JS; Masek, BB; Oldham, AA; Pearce, RJ; Rankine, N; Revill, JM New nonpeptide angiotensin II receptor antagonists. 2. Synthesis, biological properties, and structure-activity relationships of 2-alkyl-4-(biphenylylmethoxy)quinoline derivatives. J Med Chem 35:4027-38 (1992) [PubMed]  Article 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1_CAVPO | AT1 | Angiotensin II type-1 receptor
Type:
PROTEIN
Mol. Mass.:
41004.19
Organism:
Cavia porcellus
Description:
ChEMBL_36783
Residue:
359
Sequence:
MILNSSTEDGIKRIQDDCPKAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADICFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCVIIWLMAGLASLPAVIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFMFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIHDCKISDIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSTLSTKMSTLSYRPSDNVSSSAKKPVQCFEVE
  
Inhibitor
Name:
BDBM50003385
Synonyms:
4-[2'-(1H-Tetrazol-5-yl)-biphenyl-4-ylmethoxy]-quinoline | CHEMBL339592
Type:
Small organic molecule
Emp. Form.:
C23H17N5O
Mol. Mass.:
379.414
SMILES:
C(Oc1ccnc2ccccc12)c1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Structure:
Search PDB for entries with ligand similarity: