Reaction Details Report a problem with these data
Target
Sigma intracellular receptor 2
Ligand
BDBM50243653
Substrate
n/a
Meas. Tech.
ChEMBL_1672839 (CHEMBL4022868)
Ki
16±n/a nM
Citation
 Amata, E; Dichiara, M; Arena, E; Pittalą, V; Pistarą, V; Cardile, V; Graziano, ACE; Fraix, A; Marrazzo, A; Sortino, S; Prezzavento, O Novel Sigma Receptor Ligand-Nitric Oxide Photodonors: Molecular Hybrids for Double-Targeted Antiproliferative Effect. J Med Chem 60:9531-9544 (2017) [PubMed]  Article 
Target
Name:
Sigma intracellular receptor 2
Synonyms:
MAC30 | Meningioma-associated protein 30 | S2R | SGMR2_HUMAN | Sigma-2 receptor | Sigma2 receptor | TMEM97 | Transmembrane protein 97
Type:
Protein
Mol. Mass.:
20857.20
Organism:
Homo sapiens (Human)
Description:
Q5BJF2
Residue:
176
Sequence:
MGAPATRRCVEWLLGLYFLSHIPITLFMDLQAVLPRELYPVEFRNLLKWYAKEFKDPLLQEPPAWFKSFLFCELVFQLPFFPIATYAFLKGSCKWIRTPAIIYSVHTMTTLIPILSTFLFEDFSKASGFKGQRPETLHERLTLVSVYAPYLLIPFILLIFMLRSPYYKYEEKRKKK
  
Inhibitor
Name:
BDBM50243653
Synonyms:
CHEMBL4104454
Type:
Small organic molecule
Emp. Form.:
C21H24F3N3O4
Mol. Mass.:
439.4282
SMILES:
COc1cc2CCN(CCCNc3ccc(c(c3)C(F)(F)F)[N+]([O-])=O)Cc2cc1OC
Structure:
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