Reaction Details Report a problem with these data
Target
Metabotropic glutamate receptor 2/3
Ligand
BDBM50056272
Substrate
n/a
Meas. Tech.
ChEMBL_1673220 (CHEMBL4023249)
Ki
476±n/a nM
Citation
 Monn, JA; Henry, SS; Massey, SM; Clawson, DK; Chen, Q; Diseroad, BA; Bhardwaj, RM; Atwell, S; Lu, F; Wang, J; Russell, M; Heinz, BA; Wang, XS; Carter, JH; Getman, BG; Adragni, K; Broad, LM; Sanger, HE; Ursu, D; Catlow, JT; Swanson, S; Johnson, BG; Shaw, DB; McKinzie, DL; Hao, J Synthesis and Pharmacological Characterization of C4 J Med Chem 61:2303-2328 (2018) [PubMed]  Article 
Target
Name:
Metabotropic glutamate receptor 2/3
Synonyms:
Group II metabotropic glutamate receptor (mGlu2/mGlu3)
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 1673220
Components:
This complex has 2 components.
Component 1
Name:
Metabotropic glutamate receptor 2
Synonyms:
GRM2_RAT | Grm2 | Gprc1b | Mglur2
Type:
PROTEIN
Mol. Mass.:
95786.41
Organism:
Rat
Description:
ChEMBL_105034
Residue:
872
Sequence:
MESLLGFLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEECGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHSDAPTAVTGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAATQRLNASFTWVASDGWGALESVVAGSERAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEERFHCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTHLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTDDEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSFIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFVFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVAAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAPRASANLGQGSGSQFVPTVCNGREVVDSTTSSL
  
Component 2
Name:
Metabotropic glutamate receptor 3
Synonyms:
glutamate receptor, metabotropic 3 precursor | GRM3_RAT | Grm3 | Gprc1c | Mglur3
Type:
Protein
Mol. Mass.:
98971.84
Organism:
Rat
Description:
P31422
Residue:
879
Sequence:
MKMLTRLQILMLALFSKGFLLSLGDHNFMRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDNYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAANRVNASFTWVASDGWGAQESIVKGSEHVAYGAITLELASHPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRQVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKEYLLKINFTAPFNPNKGADSIVKFDTFGDGMGRYNVFNLQQTGGKYSYLKVGHWAETLSLDVDSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLVDEFTCMDCGPGQWPTADLSGCYNLPEDYIKWEDAWAIGPVTIACLGFLCTCIVITVFIKHNNTPLVKASGRELCYILLFGVSLSYCMTFFFIAKPSPVICALRRLGLGTSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILETPGTRRYTLPEKRETVILKCNVKDSSMLISLTYDVVLVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIVLFQPQKNVVTHRLHLNRFSVSGTATTYSQSSASTYVPTVCNGREVLDSTTSSL
  
Inhibitor
Name:
BDBM50056272
Synonyms:
(2S,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid | 2-Amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid(LY354740) | LY366563 | 2-Amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY 354740) | 2-Amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid | LY-354740 | CHEMBL8759 | (1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid | (1S,2S,5R,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: