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Target
Thromboxane-A synthase
Ligand
BDBM50003792
Substrate
n/a
Meas. Tech.
ChEBML_209924
IC50
1±n/a nM
Citation
 Bhagwat, SS; Gude, C; Boswell, C; Contardo, N; Cohen, DS; Dotson, R; Mathis, J; Lee, W; Furness, P; Zoganas, H Thromboxane receptor antagonism combined with thromboxane synthase inhibition. 4. 8-[[(4-Chlorophenyl)sulfonyl]amino]-4-(3-(3-pyridinyl) propyl)octanoic acid and analogs. J Med Chem 35:4373-83 (1992) [PubMed]  Article 
Target
Name:
Thromboxane-A synthase
Synonyms:
Thromboxane Alpha | Thromboxane synthase | Thromboxane-A synthase | TXA synthase | Thromboxane A2 Synthase | P450 TxA2 | Thromboxane prostanoid | Cytochrome P450 5A1 | TXS | THAS_HUMAN | TBXAS1 | CYP5 | CYP5A1 | TXAS | Thromboxane A2 Synthase (P450 TxA2)
Type:
Enzyme
Mol. Mass.:
60524.67
Organism:
Human
Description:
P24557
Residue:
533
Sequence:
MEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR
  
Inhibitor
Name:
BDBM50003792
Synonyms:
CHEMBL136762 | 8-(4-Fluoro-benzenesulfonylamino)-4-(3-pyridin-3-yl-propyl)-octanoic acid
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
OC(=O)CCC(CCCCNS(=O)(=O)c1ccc(F)cc1)CCCc1cccnc1
Structure:
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