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Target
Galectin-1
Ligand
BDBM50247477
Substrate
n/a
Meas. Tech.
ChEMBL_1677820 (CHEMBL4027963)
Kd
<10.0±n/a nM
Citation
 Peterson, K; Kumar, R; Stenström, O; Verma, P; Verma, PR; Håkansson, M; Kahl-Knutsson, B; Zetterberg, F; Leffler, H; Akke, M; Logan, DT; Nilsson, UJ Systematic Tuning of Fluoro-galectin-3 Interactions Provides Thiodigalactoside Derivatives with Single-Digit nM Affinity and High Selectivity. J Med Chem 61:1164-1175 (2018) [PubMed]  Article 
Target
Name:
Galectin-1
Synonyms:
14 kDa lectin | Galaptin | HPL | LEG1_HUMAN | LGALS1 | Lactose-binding lectin 1 | Lectin galactoside-binding soluble 1 | Putative MAPK-activating protein PM12
Type:
beta galactoside-binding protein
Mol. Mass.:
14713.53
Organism:
Homo sapiens (Human)
Description:
P09382
Residue:
135
Sequence:
MACGLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLPDGYEFKFPNRLNLEAINYMAADGDFKIKCVAFD
  
Inhibitor
Name:
BDBM50247477
Synonyms:
CHEMBL4102995
Type:
Small organic molecule
Emp. Form.:
C28H28F4N6O8S2
Mol. Mass.:
716.681
SMILES:
OC[C@H]1O[C@@H](SS[C@@H]2O[C@H](CO)[C@H](O)[C@@H]([C@H]2O)n2cc(nn2)-c2ccc(F)c(F)c2)[C@H](O)[C@H]([C@H]1O)n1cc(nn1)-c1ccc(F)c(F)c1 |r|
Structure:
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