Reaction Details Report a problem with these data
Target
Glycine receptor subunit alpha-1
Ligand
BDBM50249032
Substrate
n/a
Meas. Tech.
ChEMBL_1679678 (CHEMBL4029955)
EC50
12589±n/a nM
Citation
 Johnstone, S; Albert, JS Pharmacological property optimization for allosteric ligands: A medicinal chemistry perspective. Bioorg Med Chem Lett 27:2239-2258 (2017) [PubMed]  Article 
Target
Name:
Glycine receptor subunit alpha-1
Synonyms:
GLRA1 | GLRA1_HUMAN | Glycine receptor 48 kDa subunit | Glycine receptor strychnine-binding subunit
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52635.39
Organism:
Homo sapiens (Human)
Description:
P23415
Residue:
457
Sequence:
MYSFNTLRLYLWETIVFFSLAASKEAEAARSAPKPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKSPMLNLFQEDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQRAKKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ
  
Inhibitor
Name:
BDBM50249032
Synonyms:
CHEBI:28645 | Dietade Dietary Foods | Fructose | Levulose
Type:
Small organic molecule
Emp. Form.:
C6H12O6
Mol. Mass.:
180.1559
SMILES:
OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O |r|
Structure:
Search PDB for entries with ligand similarity: