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Target
Cytochrome P450 11B2, mitochondrial
Ligand
BDBM50249045
Substrate
n/a
Meas. Tech.
ChEMBL_1679698 (CHEMBL4029975)
IC50
14±n/a nM
Citation
 Hoyt, SB; Taylor, J; London, C; Ali, A; Ujjainwalla, F; Tata, J; Struthers, M; Cully, D; Wisniewski, T; Ren, N; Bopp, C; Sok, A; Verras, A; McMasters, D; Chen, Q; Tung, E; Tang, W; Salituro, G; Clemas, J; Zhou, G; MacNeil, D; Duffy, R; Xiong, Y Discovery of indazole aldosterone synthase (CYP11B2) inhibitors as potential treatments for hypertension. Bioorg Med Chem Lett 27:2384-2388 (2017) [PubMed]  Article 
Target
Name:
Cytochrome P450 11B2, mitochondrial
Synonyms:
Aldosterone synthase | C11B2_RAT | CYPXIB2 | Cyp11b-2 | Cyp11b2 | Cytochrome P450 11B | Cytochrome P450 11B2 | Cytochrome P450 11B2, mitochondrial | P450-Aldo-1 | Steroid 11-beta-hydroxylase
Type:
PROTEIN
Mol. Mass.:
58260.64
Organism:
Rattus norvegicus
Description:
ChEMBL_224979
Residue:
510
Sequence:
MGACDNDFIELHSRVTADVWLARPWQCLHRTRALGTTATLAPKTLKPFEAIPQYSRNKWLKMIQILREQGQENLHLEMHQAFQELGPIFRHSAGGAQIVSVMLPEDAEKLHQVESILPRRMHLEPWVAHRELRGLRRGVFLLNGAEWRFNRLKLNPNVLSPKAVQNFVPMVDEVARDFLEALKKKVRQNARGSLTMDVQQSLFNYTIEASNFALFGERLGLLGHDLNPGSLKFIHALHSMFKSTTQLLFLPRSLTRWTSTQVWKEHFDAWDVISEYANRCIWKVHQELRLGSSQTYSGIVAALITQGALPLDAIKANSMELTAGSVDTTAIPLVMTLFELARNPDVQQALRQETLAAEASIAANPQKAMSDLPLLRAALKETLRLYPVGGFLERILNSDLVLQNYHVPAGTLVLLYLYSMGRNPAVFPRPERYMPQRWLERKRSFQHLAFGFGVRQCLGRRLAEVEMLLLLHHMLKTFQVETLRQEDVQMAYRFVLMPSSSPVLTFRPIS
  
Inhibitor
Name:
BDBM50249045
Synonyms:
CHEMBL4098297
Type:
Small organic molecule
Emp. Form.:
C16H14F3N3O
Mol. Mass.:
321.2971
SMILES:
Cc1nn(-c2cncc(c2)[C@](C)(O)C(F)(F)F)c2ccccc12 |r|
Structure:
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