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Target
Ubiquitin-conjugating enzyme E2 D3
Ligand
BDBM50249761
Substrate
n/a
Meas. Tech.
ChEBML_1680604
Kd
353±n/a nM
Citation
 Chen, H; Wu, G; Gao, S; Guo, R; Zhao, Z; Yuan, H; Liu, S; Wu, J; Lu, X; Yuan, X; Yu, Z; Zu, X; Xie, N; Yang, N; Hu, Z; Sun, Q; Zhang, W Discovery of Potent Small-Molecule Inhibitors of Ubiquitin-Conjugating Enzyme UbcH5c from?-Santonin Derivatives. J Med Chem 60:6828-6852 (2017) [PubMed]  Article 
Target
Name:
Ubiquitin-conjugating enzyme E2 D3
Synonyms:
(E3-independent) E2 ubiquitin-conjugating enzyme D3 | 2.3.2.23 | 2.3.2.24 | E2 ubiquitin-conjugating enzyme D3 | UB2D3_HUMAN | UBC5C | UBCH5C | UBE2D3 | Ubiquitin carrier protein D3 | Ubiquitin-conjugating enzyme E2 D3 | Ubiquitin-conjugating enzyme E2(17)KB 3 | Ubiquitin-conjugating enzyme E2-17 kDa 3 | Ubiquitin-protein ligase D3
Type:
PROTEIN
Mol. Mass.:
16689.50
Organism:
Homo sapiens
Description:
ChEMBL_117516
Residue:
147
Sequence:
MALKRINKELSDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDPLVPEIARIYKTDRDKYNRISREWTQKYAM
  
Inhibitor
Name:
BDBM50249761
Synonyms:
CHEMBL4071335
Type:
Small organic molecule
Emp. Form.:
C22H25IO4
Mol. Mass.:
480.336
SMILES:
[H][C@@]12CC[C@@]3(C)CC[C@H](OC(=O)c4ccc(I)cc4)[C@H](C)C3[C@@]1([H])OC(=O)C2=C |r|
Structure:
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